Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent.

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Article

Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent.

Journal of lipid research - 1 Jan 1995

Minnich A, Kessling A, Roy M, Giry C, DeLangavant G, Lavigne J, Lussier-Cacan S, Davignon J

Abstract excerpt

It has previously been estimated that due to genetic "founder effects," 97% of lipoprotein lipase (LPL) gene alleles conferring type I hyperlipoproteinemia (HLP) in French Canadians encode one of the following mutant LPL forms: Gly188-->Glu, Pro207-->Leu, or Asp250-->Asn. Although the genetic basis of type I HLP is known to be homozygosity for LPL deficiency, that for other forms of HLP, especially types IV, and...

Topics

Adult
Aging
Alleles
Apolipoproteins E
Base Sequence
Canada
Female
France
Gene Frequency
Heterozygote
Humans
Hyperlipoproteinemia Type IV

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypertriglyceridemia

Lipoprotein Lipase

Lipoproteins, HDL

Lipoproteins, LDL

Male

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7706936

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7706936-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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