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Article

Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent.

Journal of lipid research - 1 Jan 1995

Minnich A, Kessling A, Roy M, Giry C, DeLangavant G, Lavigne J, Lussier-Cacan S, Davignon J

Abstract excerpt

It has previously been estimated that due to genetic "founder effects," 97% of lipoprotein lipase (LPL) gene alleles conferring type I hyperlipoproteinemia (HLP) in French Canadians encode one of the following mutant LPL forms: Gly188-->Glu, Pro207-->Leu, or Asp250-->Asn. Although the genetic basis of type I HLP is known to be homozygosity for LPL deficiency, that for other forms of HLP, especially types IV, and...

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Identifiers

PMID: 7706936

Genes

LPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent.PMID 7706936Read ↗

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A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in French Canadians.Semantic proximity Read ↗

Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians.Semantic proximity Read ↗

Hypertriglyceridaemia due to genetic defects in lipoprotein lipase and apolipoprotein C-II.Semantic proximity Read ↗

Support for founder effect for two lipoprotein lipase (LPL) gene mutations in French Canadians by analysis of GT microsatellites flanking the LPL gene.Semantic proximity Read ↗

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