Article
Support for founder effect for two lipoprotein lipase (LPL) gene mutations in French Canadians by analysis of GT microsatellites flanking the LPL gene.
Human genetics - 1 May 1993
Wood S, Schertzer M, Hayden M, Ma Y
Abstract excerpt
Mutations in the human lipoprotein lipase (LPL) gene are one of the major causes of familial chylomicronemia. We have characterized two polymorphic GT microsatellites flanking this gene. Two LPL mutations that are extremely frequent in French Canadians appear to be in complete linkage disequilibr...
Topics
- Adult
- Alleles
- Base Sequence
- Canada
- Chi-Square Distribution
- Child
- DNA Mutational Analysis
- DNA, Satellite
- Female
- France
- Gene Frequency
- Haplotypes
- Humans
- Hyperlipoproteinemia Type I
- Linkage Disequilibrium
- Lipoprotein Lipase
- Male
- Molecular Sequence Data