Article
Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency.
Diabetes - 1 Dec 1997
Julien P, Vohl M C, Gaudet D, Gagné C, Lévesque G, Després J P, Cadelis F, Brun L D, Nadeau A, Ven Murthy M R
Abstract excerpt
We have reported three missense mutations (G188E, P207L, and D250N) in the lipoprotein lipase (LPL) gene among French-Canadians, resulting in the absence of measurable postheparin plasma LPL activity in homozygotes. Presence of triglyceride- and cholesterol-rich VLDL, as well as cholesterol-poor HDL particles, has been shown in heterozygotes affected by partial reduction in postheparin LPL activity. However,...
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