Article
A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in French Canadians.
The New England journal of medicine - 20 Jun 1991
Ma Y, Henderson H E, Murthy V, Roederer G, Monsalve M V, Clarke L A, Normand T, Julien P, Gagné C, Lambert M
Abstract excerpt
BACKGROUND: Lipoprotein lipase hydrolyzes the triglyceride core of chylomicrons and very-low-density lipoproteins and has a crucial role in regulating plasma lipoprotein levels. Deficiencies of lipoprotein lipase activity lead to aberrations in lipoprotein levels. Worldwide, the frequency of lipoprotein lipase deficiency is highest among French Canadians. We sought to determine the molecular basis of the disorder...
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