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Molecular characterisation of mutations associated with resistance to first- and second-line drugs among Indonesian patients with tuberculosis

1 Feb 2020

Abstract excerpt

conferred rifampicin-resistance on M. tuberculosis.Approximately 11.42% (4/35) of isolates with S315T mutation in katG led to rifampicin-resistance instead of isoniazid-resistance.The mutation in katG gene was found at various locations (P280P, G279R, E340Q, T271I, E340*stop codon, R373G, and S315N).Streptomycin-resistance was detected in 42% (21/50) of the strains, but only two strains had rrs gene mutations...

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Identifiers

PMID: 32110183
DOI: 10.1016/j.jtumed.2019.12.003

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