Article
Usefulness of immunohistochemical staining for p53 in the prognosis of breast carcinomas: correlations with established prognosis parameters and with the proliferation marker, MIB-1.
Gynecologic oncology - 1 Apr 1995
Beck T, Weller E E, Weikel W, Brumm C, Wilkens C, Knapstein P G
Abstract excerpt
Mutations of the p53 gene often result in the overexpression of p53 protein. Previous studies have suggested that the function of p53 and its mutant protein forms may be linked with the disease course of patients with a breast carcinoma. In the present study, we tested 462 primary breast carcinom...
Topics
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Breast Neoplasms
- Cell Division
- Cell Nucleus
- Disease-Free Survival
- Female
- Humans
- Immunohistochemistry
- Mutation
- Prognosis
- Regression Analysis
- Survival Analysis
- Tumor Suppressor Protein p53