An antagonistic mutant of interleukin-4 fails to recruit gamma c into the receptor complex. Characterization by specific crosslinking.

Article

An antagonistic mutant of interleukin-4 fails to recruit gamma c into the receptor complex. Characterization by specific crosslinking.

European journal of biochemistry - 1 Mar 1995

Duschl A

Abstract excerpt

The receptor for interleukin-4 (IL-4) appears to be a heterodimer of the IL-4-binding protein IL-4R alpha and the gamma c chain. Mutations of IL-4 have previously identified a region of IL-4 essential for signaling, which was suggested to bind gamma c. Here it is shown by crosslinking of radiolab...

Topics

Humans
Immunoglobulin G
Interleukin-4
Mutation
Receptors, Interleukin-4
Receptors, Mitogen
Tumor Cells, Cultured

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