Article
Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus.
Arthritis and rheumatism - 1 Oct 1990
Fronek Z, Timmerman L A, Alper C A, Hahn B H, Kalunian K, Peterlin B M, McDevitt H O
Abstract excerpt
Susceptibility to systemic lupus erythematosus is associated with major histocompatibility complex (MHC)--encoded genes. We have used nucleotide sequence analysis to better define the disease-associated MHC alleles. HLA-DR2, DQw1, and especially the rare allele DQ beta 1. AZH confer high relative...
Topics
- Alleles
- Complement System Proteins
- Disease Susceptibility
- Genes, Regulator
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR4 Antigen
- Histocompatibility Antigens Class II
- Humans
- Lupus Erythematosus, Systemic
- Major Histocompatibility Complex
- Pilot Projects
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Risk Factors