Article
HLA-DR and -DQ genotyping in anti-GBM disease.
Disease markers - 1 Jan 2000
Dunckley H, Chapman J R, Burke J, Charlesworth J, Hayes J, Haywood E, Hutchison B, Ibels L, Kalowski S, Kincaid-Smith P
Abstract excerpt
Anti-GBM disease has been associated with the HLA genes of the major histocompatibility complex (MHC) in previous serological studies, with an increased incidence of HLA-DR2 in patients. In this study, 36 patients with anti-GBM disease were genotyped by restriction fragment length polymorphism (RFLP) analysis using cDNA probes for DRB, DQA, and DQB. The frequency of HLA-DRw15(Dw2), a split of DR2, was...
Topics
- Adolescent
- Adult
- Aged
- Anti-Glomerular Basement Membrane Disease
- Female
- Genes, MHC Class II
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Male
- Middle Aged