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Article

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.

Kidney international - 1 Dec 1994

Whitworth C E, Fleming S, Cumming A D, Morton J J, Burns N J, Williams B C, Mullins J J

Abstract excerpt

Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid...

Topics

Animals
Animals, Genetically Modified
Blood Pressure
Disease Models, Animal
Female
Heterozygote
Humans
Hypertension, Malignant
Kidney
Male
Phenotype
Rats
Rats, Inbred Lew

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Sprague-Dawley

Sodium, Dietary

Source

Identifiers

PMID: 7699997
DOI: 10.1038/ki.1994.437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7699997-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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