Evolution of hereditary bowel cancer.

Abstract excerpt

Familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC) are both inherited as autosomal dominant conditions in which the mutation gives rise to a tendency to produce precancerous adenomas. However these two forms of hereditary bowel cancer show important differences at the clinical, pathological and molecular genetic levels. It is argued that the first tissue manifestation of...

Topics

• Adenoma
• Adenomatous Polyposis Coli
• Animals
• Colorectal Neoplasms
• Humans
• Mutation