Article
Pathogenesis of colorectal cancer.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Dec 2000
Ponz de Leon M, Percesepe A
Abstract excerpt
The development of colorectal cancer has been viewed as an ordered process in which three main phases can be identified: initiation, promotion and progression. There is definite proof that stable alterations of the structure or sequence of DNA (mutations) represent the initiating event; these are followed by an uncontrolled expansion of the neoplastic clones which characterizes tumoural growth. Several classes of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.