Article
Two defective forms of reverse transcriptase can complement to restore retroviral infectivity.
The EMBO journal - 1 Nov 1993
Telesnitsky A, Goff S P
Abstract excerpt
Retroviral DNA synthesis requires both the DNA polymerase and the RNaseH activities of reverse transcriptase (RT). To test whether two defective RTs--one carrying a mutation in the RNaseH domain and the other with a mutation in DNA polymerase--could work together to complete viral DNA synthesis,...
Topics
- 3T3 Cells
- Animals
- DNA Nucleotidyltransferases
- DNA-Directed DNA Polymerase
- Genetic Complementation Test
- Integrases
- Mice
- Moloney murine leukemia virus
- Mutation
- Phenotype
- Proviruses
- RNA-Directed DNA Polymerase
- Rats
- Retroviridae Proteins
- Ribonuclease H
- Virion
- Virulence
- Virus Integration