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Article

Two defective forms of reverse transcriptase can complement to restore retroviral infectivity.

The EMBO journal - 1 Nov 1993

Telesnitsky A, Goff S P

Abstract excerpt

Retroviral DNA synthesis requires both the DNA polymerase and the RNaseH activities of reverse transcriptase (RT). To test whether two defective RTs--one carrying a mutation in the RNaseH domain and the other with a mutation in DNA polymerase--could work together to complete viral DNA synthesis, we generated phenotypically mixed virions of Moloney murine leukemia virus (M-MuLV) that contained two kinds of mutant...

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Identifiers

PMID: 7693456
DOI: 10.1002/j.1460-2075.1993.tb06128.x
PMCID: PMC413742

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Source receipt: pubmed, retrieved 7 Sept 2026.

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