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Article

Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.

Journal of virology - 1 Jul 1995

Blain S W, Goff S P

Abstract excerpt

To determine the various roles of RNase H in reverse transcription, we generated a panel of mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase based on sequence alignments and the crystal structures of Escherichia coli and human immunodeficiency virus type 1 RNases H (S. W. Blain and S. P. Goff, J. Biol. Chem. 268:23585-23592, 1993). These mutations were introduced into a...

Topics

3T3 Cells
Animals
Base Sequence
Biological Transport
DNA, Viral
Mice
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
RNA, Viral
RNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribonuclease H

Structure-Activity Relationship

Viral Proteins

Virion

Virus Replication

Source

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Identifiers

PMID: 7539510
DOI: 10.1128/JVI.69.7.4440-4452.1995
PMCID: PMC189186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7539510-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.PMID 7539510Read ↗

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