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Article

Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.

Journal of virology - 1 Jul 1995

Blain S W, Goff S P

Abstract excerpt

To determine the various roles of RNase H in reverse transcription, we generated a panel of mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase based on sequence alignments and the crystal structures of Escherichia coli and human immunodeficiency virus type 1 RNases H (S. W. Blain and S. P. Goff, J. Biol. Chem. 268:23585-23592, 1993). These mutations were introduced into a...

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Identifiers

PMID: 7539510
DOI: 10.1128/JVI.69.7.4440-4452.1995
PMCID: PMC189186

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Source receipt: pubmed, retrieved 7 Sept 2026.

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