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Article

Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function.

The Journal of biological chemistry - 25 Apr 1997

Palaniappan C, Wisniewski M, Jacques P S, Le Grice S F, Fay P J, Bambara R A

Abstract excerpt

Human immunodeficiency virus (HIV) DNA synthesis is accompanied by degradation of genomic RNA by the RNase H of reverse transcriptase (RT). Two different modes of RNase H activity appear necessary for complete RNA removal. In one, occurring during minus strand synthesis, positioning of the RNase H is determined by binding of the polymerase active site to the DNA 3'-end. In the other, used for removal of remaining...

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Identifiers

PMID: 9111014
DOI: 10.1074/jbc.272.17.11157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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