Article
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase.
Journal of virology - 1 Nov 1992
DeStefano J J, Mallaber L M, Rodriguez-Rodriguez L, Fay P J, Bambara R A
Abstract excerpt
We have examined the ability of the reverse transcriptase (RT) from human immunodeficiency virus (HIV) to carry out strand transfer synthesis (i.e., switching of the primer to a new template) from internal regions of natural-sequence RNA. A 142-nucleotide RNA template (donor) primed with a specif...
Topics
- Base Sequence
- DNA, Viral
- Escherichia coli
- HIV
- Leukemia Virus, Murine
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- RNA, Viral
- RNA-Directed DNA Polymerase
- Recombinant Proteins
- Ribonuclease H
- Substrate Specificity
- Templates, Genetic
- Transcription, Genetic