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Article

Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase.

Journal of virology - 1 Nov 1992

DeStefano J J, Mallaber L M, Rodriguez-Rodriguez L, Fay P J, Bambara R A

Abstract excerpt

We have examined the ability of the reverse transcriptase (RT) from human immunodeficiency virus (HIV) to carry out strand transfer synthesis (i.e., switching of the primer to a new template) from internal regions of natural-sequence RNA. A 142-nucleotide RNA template (donor) primed with a specific 20-nucleotide DNA oligonucleotide was used to initiate synthesis. DNA oligonucleotides with homology to internal...

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Identifiers

PMID: 1383563
DOI: 10.1128/JVI.66.11.6370-6378.1992
PMCID: PMC240129

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