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Article

Activation interferes with the APO-1 pathway in mature human T cells.

International immunology - 1 Jun 1993

Klas C, Debatin K M, Jonker R R, Krammer P H

Abstract excerpt

One of the mechanisms to terminate a specific immune response may involve elimination of antigen activated T cells by programmed cell death, apoptosis. Apoptosis in activated T cells may be induced via the TCR-CD3 complex or/and cell surface molecules like the APO-1 (Fas) antigen, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily. To investigate apoptosis in activated T cells we...

Topics

Antigens, Surface
Apoptosis
Cell Differentiation
Cycloheximide
Dactinomycin
Humans
In Vitro Techniques
Lymphocyte Activation
Phenotype
T-Lymphocytes
fas Receptor

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Identifiers

PMID: 7688561
DOI: 10.1093/intimm/5.6.625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7688561-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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