Article
Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
Behring Institute Mitteilungen - 1 Jun 1995
Dhein J, Walczak H, Westendorp M O, Bäumler C, Stricker K, Frank R, Debatin K M, Krammer P H
Abstract excerpt
The cell surface molecule APO-1/Fas(CD95), a member of the Tumor Necrosis Factor (TNF) receptor/Nerve Growth Factor (NGF) receptor superfamily mediates apoptosis upon cross-linking by agonistic antibodies or its ligand. Recent findings suggest that APO-1/Fas(CD95) and its ligand are the key molec...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Antigens, CD
- Apoptosis
- Autoimmune Diseases
- Humans
- Immune Tolerance
- Models, Immunological
- Mutation
- Receptors, Nerve Growth Factor
- Receptors, Tumor Necrosis Factor
- T-Lymphocytes
- fas Receptor