Article
Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
Behring Institute Mitteilungen - 1 Jun 1995
Dhein J, Walczak H, Westendorp M O, Bäumler C, Stricker K, Frank R, Debatin K M, Krammer P H
Abstract excerpt
The cell surface molecule APO-1/Fas(CD95), a member of the Tumor Necrosis Factor (TNF) receptor/Nerve Growth Factor (NGF) receptor superfamily mediates apoptosis upon cross-linking by agonistic antibodies or its ligand. Recent findings suggest that APO-1/Fas(CD95) and its ligand are the key molecules for antigen receptor-induced apoptosis in activated mature T cells. Here we propose a mechanism for antigen...
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