Article
Susceptibility to cell death is a dominant phenotype: triggering of activation-driven T-cell death independent of the T-cell antigen receptor complex.
Molecular and cellular biology - 1 Jan 1992
Nickas G, Meyers J, Hebshi L D, Ashwell J D, Gold D P, Sydora B, Ucker D S
Abstract excerpt
The failure of Thy-1 and Ly-6 to trigger interleukin-2 production in the absence of surface T-cell antigen receptor complex (TCR) expression has been interpreted to suggest that functional signalling via these phosphatidylinositol-linked alternative activation molecules is dependent on the TCR. We find, in contrast, that stimulation of T cells via Thy-1 or Ly-6 in the absence of TCR expression does trigger a...
Topics
- Animals
- Antigens, Ly
- Antigens, Surface
- Cell Death
- Genes, Dominant
- Kinetics
- Lymphocyte Activation
- Lymphokines
- Mice
- Phenotype
- Rats