Article
Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1993
Temin H M
Abstract excerpt
Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.
Topics
- Genetic Variation
- Mutation
- RNA, Viral
- RNA-Directed DNA Polymerase
- Recombination, Genetic
- Retroviridae
- Sequence Deletion
- Templates, Genetic
- Virus Replication