Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A respiratory syncytial virus trailer sequence modulates viral replication and the generation and propagation kinetics of copy-back defective viral genomes.

Journal of virology - 21 Apr 2026

Brennan Justin W, Wang Gaochan, Connor Sarah, Wang Xingjian, Mariani Thomas J, Sun Yan

Abstract excerpt

Copy-back defective viral genomes (cbDVGs) are key inducers of antiviral responses during negative-sense RNA virus infection. Once considered byproducts of in vitro viral replication, cbDVGs have since been detected in clinical specimens and implicated in affecting infection outcomes. The molecular mechanism of cbDVG generation remains unclear, thereby hindering our ability to manipulate cbDVG production during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Defective Viruses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Kinetics

Share to Respiratory Syncytial Virus, Human

Share to Respiratory Syncytial Virus Infections

Share to RNA, Viral

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 41874044
DOI: 10.1128/jvi.00184-26
PMCID: PMC13098259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A respiratory syncytial virus trailer sequence modulates viral replication and the generation and propagation kinetics of copy-back defective viral genomes.PMID 41874044Read ↗

A Respiratory Syncytial Virus trailer sequence modulates viral replication and copy-back defective viral genome generation and propagation kineticsSemantic proximity Read ↗

A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomesSemantic proximity Read ↗

A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomesSemantic proximity Read ↗

Accumulation of copy-back viral genomes during respiratory syncytial virus infection is preceded by diversification of the copy-back viral genome population followed by selectionSemantic proximity Read ↗

Accumulation of copy-back viral genomes during respiratory syncytial virus infection is preceded by diversification of the copy-back viral genome population followed by selectionSemantic proximity Read ↗

SARS-CoV-2 Defective Viral Genomes from Distinct Genomic Regions Drive Divergent Interferon ResponsesSemantic proximity Read ↗

Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation.Semantic proximity Read ↗

Mutations in the 5' trailer region of a respiratory syncytial virus minigenome which limit RNA replication to one step.Semantic proximity Read ↗

Validation of diverse and previously untraceable Sendai virus copyback viral genomes by direct RNA sequencingSemantic proximity Read ↗

Development, applications, and future prospects of RNA virus reverse genetics technologySemantic proximity Read ↗

The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate.Semantic proximity Read ↗

Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural processSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.