Mutation Rates, Mutation Frequencies, and Proofreading-Repair Activities in RNA Virus Genetics.

doi:10.3390/v13091882

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Article

Mutation Rates, Mutation Frequencies, and Proofreading-Repair Activities in RNA Virus Genetics.

Viruses - 21 Sept 2021

Domingo Esteban, García-Crespo Carlos, Lobo-Vega Rebeca, Perales Celia

Abstract excerpt

The error rate displayed during template copying to produce viral RNA progeny is a biologically relevant parameter of the replication complexes of viruses. It has consequences for virus-host interactions, and it represents the first step in the diversification of viruses in nature. Measurements during infections and with purified viral polymerases indicate that mutation rates for RNA viruses are in the range of...

Topics

Animals
Biological Evolution
Coronavirus
Exonucleases
Genetic Variation
Genome, Viral
Humans
Mutation
Mutation Rate
RNA Virus Infections
RNA Viruses
RNA, Viral
Virus Replication

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Identifiers

PMID: 34578463
DOI: 10.3390/v13091882
PMCID: PMC8473064

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