Running the gamut of retroviral variation.

doi:10.1016/0966-842x(96)10023-8

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Article

Running the gamut of retroviral variation.

Trends in microbiology - 1 Apr 1996

Wain-Hobson S

Abstract excerpt

The retroviral DNA polymerase, or reverse transcriptase, lacks a 3' exonuclease proofreading activity. This causes a high mutation rate with the result that genetic diversity and drug resistance are increased. Only combination chemotherapy has the potential to out-manoeuvre these viruses. However...

Topics

Animals
Genetic Variation
HIV
HIV Infections
Human T-lymphotropic virus 1
Humans
Retroviridae
Retroviridae Infections
Simian Immunodeficiency Virus

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