Article
Echinomycin, a bis-intercalating agent, induces C-->T mutations via cytosine deamination.
Mutation research - 1 Aug 1993
Moyer R, Briley D, Johnsen A, Stewart U, Shaw B R
Abstract excerpt
Echinomycin, a bis-intercalating, antitumor drug, has been studied for its ability to induce the deamination of cytosine to uracil (C-->U) in double-stranded DNA. We have employed a sensitive lacZ alpha-complementation reversion assay to detect G.C-->A.T mutations at a number of sites in M13mp2 D...
Topics
- Base Sequence
- Cell Line
- Cytosine
- Deamination
- Echinomycin
- Intercalating Agents
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Temperature
- Transfection