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Article

Echinomycin, a bis-intercalating agent, induces C-->T mutations via cytosine deamination.

Mutation research - 1 Aug 1993

Moyer R, Briley D, Johnsen A, Stewart U, Shaw B R

Abstract excerpt

Echinomycin, a bis-intercalating, antitumor drug, has been studied for its ability to induce the deamination of cytosine to uracil (C-->U) in double-stranded DNA. We have employed a sensitive lacZ alpha-complementation reversion assay to detect G.C-->A.T mutations at a number of sites in M13mp2 DNA to determine the extent to which distortions of DNA structure induced by echinomycin may affect C-->U rates. When...

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Identifiers

PMID: 7688090
DOI: 10.1016/0027-5107(93)90097-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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