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Article

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase.

The Journal of biological chemistry - 10 Nov 2017

Taskinen Barbara, Ferrada Evandro, Fowler Douglas M

Abstract excerpt

Stringent regulation of tyrosine kinase activity is essential for normal cellular function. In humans, the tyrosine kinase Src is inhibited via phosphorylation of its C-terminal tail by another kinase, C-terminal Src kinase (Csk). Although Src and Csk orthologs are present across holozoan organisms, including animals and protists, the Csk-Src negative regulatory mechanism appears to have evolved gradually. For...

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Identifiers

PMID: 28939764
DOI: 10.1074/jbc.M117.811174
PMCID: PMC5682962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase.PMID 28939764Read ↗

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