Article
CD4+ T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1993
Moreno A, Clavijo P, Edelman R, Davis J, Sztein M, Sinigaglia F, Nardin E
Abstract excerpt
CD4+ T cell clones were derived from three volunteers who were protected against malaria after immunization with Plasmodium falciparum sporozoites. T cells specific for an epitope, Pf Th/Tc, contained in amino acids 326 to 345 of the circumsporozoite (CS) protein of P. falciparum (NF54) were deri...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigens, Protozoan
- CD4-Positive T-Lymphocytes
- Epitopes
- HLA-D Antigens
- HLA-DR Antigens
- Humans
- Lymphocyte Activation
- Lymphokines
- Malaria, Falciparum
- Molecular Sequence Data
- Peptides
- Plasmodium falciparum