Article
Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line.
Biochemical pharmacology - 12 Sept 1991
Bayad J, Bagrel D, Sabolovic N, Magdalou J, Siest G
Abstract excerpt
A hepatic cell line has been immortalized after simian vacuolating virus 40 infection of adult rat hepatocytes maintained in defined culture conditions. This cell line, designated SVHep B4, expressed nuclear large T antigen, exhibited an extended lifespan (50 subcultures) and had a hepatocyte-lik...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Cell Transformation, Viral
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP2B1
- Cytochrome P-450 Enzyme System
- Dexamethasone
- Enzyme Induction
- Liver
- Male
- Methylcholanthrene
- Microsomes, Liver
- Oxidoreductases
- Phenobarbital
- Phenotype
- Rats
- Rats, Inbred Strains