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Article

Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line.

Biochemical pharmacology - 12 Sept 1991

Bayad J, Bagrel D, Sabolovic N, Magdalou J, Siest G

Abstract excerpt

A hepatic cell line has been immortalized after simian vacuolating virus 40 infection of adult rat hepatocytes maintained in defined culture conditions. This cell line, designated SVHep B4, expressed nuclear large T antigen, exhibited an extended lifespan (50 subcultures) and had a hepatocyte-like morphology. Expression and regulation of drug metabolizing enzymes were studied in long-term cultures of SVHep B4...

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Identifiers

PMID: 1681808
DOI: 10.1016/0006-2952(91)90444-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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