Article
Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex.
AIDS (London, England) - 1 Apr 1995
Wainberg M A, Salomon H, Gu Z, Montaner J S, Cooley T P, McCaffrey R, Ruedy J, Hirst H M, Cammack N, Cameron J
Abstract excerpt
OBJECTIVE: To determine the rate of development of in vitro HIV resistance to (-)2'-deoxy-3'-thiacytidine (3TC) and relate the effect of dose to emergence of resistance. METHODS: HIV-infected men and non-pregnant women, aged > or = 18 years, with a CD4 count < or = 300 x 10(6)/l cells were follow...
Topics
- AIDS-Related Complex
- Acquired Immunodeficiency Syndrome
- Adolescent
- Adult
- Base Sequence
- DNA Primers
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Female
- HIV Reverse Transcriptase
- HIV-1
- Humans
- In Vitro Techniques
- Lamivudine