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Article

Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.

Antimicrobial agents and chemotherapy - 1 Oct 1994

Nguyen M H, Schinazi R F, Shi C, Goudgaon N M, McKenna P M, Mellors J W

Abstract excerpt

Acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidine derivatives are potent and specific inhibitors of human immunodeficiency virus type 1 (HIV-1). The development of in vitro resistance to two derivatives, 5-ethyl-1-(ethoxymethyl)-(6-phenylthio)-uracil (E-EPU), was evaluated by serial passage of HIV-1 in increasing concentrations of inhibitor. HIV-1 variants exhibiting > 500-fold resistance to E-EPSeU and E-EPU...

Topics

Antiviral Agents
Drug Resistance
HIV-1
Humans
Mutation
Organoselenium Compounds
Structure-Activity Relationship
Uracil
Zidovudine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7840579
DOI: 10.1128/AAC.38.10.2409
PMCID: PMC284753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7840579-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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