Enhanced sensitivity of Escherichia coli uvrB mutants to mitomycin C points to a UV-C distinct repair for DNA adducts.

doi:10.1021/tx060035y

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Article

Enhanced sensitivity of Escherichia coli uvrB mutants to mitomycin C points to a UV-C distinct repair for DNA adducts.

Chemical research in toxicology - 1 Oct 2006

Vidal Leonardo S, Santos Larissa B, Lage Claudia, Leitão Alvaro C

Abstract excerpt

Nucleotide excision repair (NER) in Escherichia coli repairs DNA by incising the damaged strand on the 3' and 5' sides of the lesion within pyrimidine dimers and DNA cross-linking adducts. Cross-linking adducts belong to a class of chemical damage to DNA that prevent strand separation, and thus, replication and transcription. For this reason, cross-linking agents such as mitomycin C (MC) have been used in cancer...

Topics

Cell Survival
DNA Adducts
DNA Helicases
DNA Repair
Escherichia coli
Escherichia coli Proteins
Mitomycin
Mutation
Rec A Recombinases
Sensitivity and Specificity
Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 17040104
DOI: 10.1021/tx060035y

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