Article
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots.
The Journal of biological chemistry - 15 May 1993
Bebenek K, Abbotts J, Wilson S H, Kunkel T A
Abstract excerpt
We have observed previously that DNA template-directed polymerization by the type 1 human immunodeficiency virus reverse transcriptase is error-prone for single-nucleotide substitution, addition and deletion errors at homopolymeric sequences. We have also noted strong termination of processive synthesis at these positions (Bebenek, K., Abbotts, J., Roberts, J. D., Wilson, S. H., and Kunkel, T. A. (1989) J. Biol....
Topics
- Base Sequence
- DNA Replication
- DNA, Viral
- Escherichia coli
- Genetic Code
- HIV Reverse Transcriptase
- HIV-1
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Probability