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Article

Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Patel P H, Preston B D

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) is genetically highly variable. This is attributed to the error-prone nature of HIV-1 replication and its proclivity for recombination. During replication and recombination, reverse transcriptase (RT) must polymerize DNA to the 5' ends of multiple RNA and DNA template termini while converting HIV-1 RNA to double-stranded DNA. We have determined the fidelity of HIV-1 RT...

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Identifiers

PMID: 7507249
DOI: 10.1073/pnas.91.2.549
PMCID: PMC42986

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