Article
Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994
Patel P H, Preston B D
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) is genetically highly variable. This is attributed to the error-prone nature of HIV-1 replication and its proclivity for recombination. During replication and recombination, reverse transcriptase (RT) must polymerize DNA to the 5' ends of multiple RNA a...
Topics
- Base Sequence
- DNA Primers
- DNA Replication
- DNA, Viral
- HIV Long Terminal Repeat
- HIV Reverse Transcriptase
- HIV-1
- In Vitro Techniques
- Models, Genetic
- Molecular Sequence Data
- Mutation
- RNA, Viral
- RNA-Directed DNA Polymerase
- Virus Replication