Article
Frameshift errors initiated by nucleotide misincorporation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Bebenek K, Kunkel T A
Abstract excerpt
Studies presented here on the fidelity of DNA synthesis in vitro support the hypothesis that a classical base-substitution intermediate (i.e., a misincorporated nucleotide) can yield a frameshift mutation. By using a fidelity assay specifically designed to detect minus-one-base errors, nucleotide...
Topics
- Base Composition
- Base Sequence
- Coliphages
- DNA
- DNA, Viral
- DNA-Directed DNA Polymerase
- Deoxyribonucleotides
- Escherichia coli
- Indicators and Reagents
- Molecular Sequence Data
- Mutation