Article
Frameshift errors initiated by nucleotide misincorporation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Bebenek K, Kunkel T A
Abstract excerpt
Studies presented here on the fidelity of DNA synthesis in vitro support the hypothesis that a classical base-substitution intermediate (i.e., a misincorporated nucleotide) can yield a frameshift mutation. By using a fidelity assay specifically designed to detect minus-one-base errors, nucleotide substrate pool imbalances that have previously been shown to increase the rate of misincorporation are now shown to...
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