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Article

Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase.

The Journal of biological chemistry - 17 Mar 2006

Hamburgh Monica E, Curr Kenneth A, Monaghan Melissa, Rao Vasudev R, Tripathi Snehlata, Preston Bradley D, Sarafianos Stefan, Arnold Eddy, Darden Thomas, Prasad Vinayaka R

Abstract excerpt

Single-base deletions at nucleotide runs or -1 frameshifting by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) result from template slippage during polymerization. In crystal structures of HIV-1 RT complexed with DNA-DNA template-primer, the palm subdomain in the template cleft contacts the template backbone near the proposed site of slippage via the Glu(89) side chain. We investigated the...

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PMID: 16423828
DOI: 10.1074/jbc.M511380200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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