Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand.

doi:10.1006/dbio.1993.1122

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Article

Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand.

Developmental biology - 1 May 1993

Marziali G, Lazzaro D, Sorrentino V

Abstract excerpt

Mutations in the steel (Sl) locus, encoding the c-kit ligand (KL), are associated with impaired germ cell development in mice. Two forms of KL exist: one more steadily associated with the plasma membrane and one more easily released as a soluble protein. We report here that the expression of the...

Topics

Aging
Animals
Base Sequence
Cloning, Molecular
Gene Expression Regulation
Hematopoietic Cell Growth Factors
Male
Membrane Fusion
Mice
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Specificity

Polymerase Chain Reaction

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-kit

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7683283
DOI: 10.1006/dbio.1993.1122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7683283-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand.PMID 7683283Read ↗

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.Semantic proximity Read ↗

Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice.Semantic proximity Read ↗

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.Semantic proximity Read ↗

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockoutsSemantic proximity Read ↗

Expression of the mRNA for the ligand of C-kit in mouse sertoli cellsSemantic proximity Read ↗

Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.Semantic proximity Read ↗

The kit ligand: a cell surface molecule altered in steel mutant fibroblasts.Semantic proximity Read ↗

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