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Article

Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand.

Developmental biology - 1 May 1993

Marziali G, Lazzaro D, Sorrentino V

Abstract excerpt

Mutations in the steel (Sl) locus, encoding the c-kit ligand (KL), are associated with impaired germ cell development in mice. Two forms of KL exist: one more steadily associated with the plasma membrane and one more easily released as a soluble protein. We report here that the expression of the two mRNAs coding for the two different form of KL is developmentally regulated in mouse testis. At birth the two mRNAs...

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Identifiers

PMID: 7683283
DOI: 10.1006/dbio.1993.1122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand.PMID 7683283Read ↗

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.Semantic proximity Read ↗

Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice.Semantic proximity Read ↗

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.Semantic proximity Read ↗

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockoutsSemantic proximity Read ↗

Expression of the mRNA for the ligand of C-kit in mouse sertoli cellsSemantic proximity Read ↗

Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.Semantic proximity Read ↗

The kit ligand: a cell surface molecule altered in steel mutant fibroblasts.Semantic proximity Read ↗

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