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Article

Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration.

PloS one - 1 Jan 2011

Gu Ying, Runyan Christopher, Shoemaker Amanda, Surani M Azim, Wylie Christopher

Abstract excerpt

Steel factor, the protein product of the Steel locus in the mouse, is a multifunctional signal for the primordial germ cell population. We have shown previously that its expression accompanies the germ cells during migration to the gonads, forming a "travelling niche" that controls their survival, motility, and proliferation. Here we show that these functions are distributed between the alternatively spliced...

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Identifiers

PMID: 21998739
DOI: 10.1371/journal.pone.0025984
PMCID: PMC3188585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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