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Article

Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen.

The Journal of biological chemistry - 15 Dec 2000

Fujise K, Zhang D, Liu J, Yeh E T

Abstract excerpt

MCL1 (ML1 myeloid cell leukemia 1), a Bcl-2 (B- cell lymphoma-leukemia 2) homologue, is known to function as an anti-apoptotic protein. Here we show in vitro and in vivo that MCL1 interacts with the cell cycle regulator, proliferating cell nuclear antigen (PCNA). This finding prompted us to investigate whether MCL1, in addition to its anti-apoptotic function, has an effect on cell cycle progression. A...

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Source

Identifiers

PMID: 10978339
DOI: 10.1074/jbc.M006626200

Genes

MCL1
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen.PMID 10978339Read ↗

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