Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mcl-1 as a therapeutic target in acute myelogenous leukemia (AML)

1 Jan 2013

Abstract excerpt

The B-cell lymphoma-2 (Bcl-2) family of proteins regulates the intrinsic, or mitochondrial pathway of apoptosis, the final common mechanism of cell death in response to a variety of physiologic and pharmacologic signals, and plays a central role in AML pathogenesis, prognosis and responsiveness to chemotherapy. Traditionally thought to be an important survival factor for multiple myeloma cells, the anti-apoptotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer therapeutics and mechanisms
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23977453
DOI: 10.1016/j.lrr.2012.11.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mcl-1 as a therapeutic target in acute myelogenous leukemia (AML)PMID 23977453Read ↗

Emerging therapies for acute myeloid leukemia: translating biology into the clinic.Semantic proximity Read ↗

An Overview of Targeted Therapies in Acute Myeloid LeukemiaSemantic proximity Read ↗

Mcl‐1 targeting could be an intriguing perspective to cure cancerSemantic proximity Read ↗

Mcl-1 inhibitors: a patent reviewSemantic proximity Read ↗

The multiple mechanisms of MCL1 in the regulation of cell fateSemantic proximity Read ↗

Novel therapeutic strategies for AML in 2012.Semantic proximity Read ↗

Toward Targeting Antiapoptotic MCL-1 for Cancer TherapySemantic proximity Read ↗

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemiaSemantic proximity Read ↗

Targeting Apoptosis in AML: Where Do We Stand?Semantic proximity Read ↗

Update on Small Molecule Targeted Therapies for Acute Myeloid Leukemia.Semantic proximity Read ↗

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial MetabolismSemantic proximity Read ↗

Advances in the pharmacological management of acute myeloid leukemia in adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.