Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

Blood - 1 Nov 2008

Pepper Chris, Lin Thet Thet, Pratt Guy, Hewamana Saman, Brennan Paul, Hiller Louise, Hills Robert, Ward Rachel, Starczynski Jane, Austen Belinda, Hooper Laura, Stankovic Tatjana, Fegan Chris

Abstract excerpt

Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase 1
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Proto-Oncogene Proteins c-bcl-2

Share to Vidarabine

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 18599795
DOI: 10.1182/blood-2008-05-157131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.PMID 18599795Read ↗

Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemiaSemantic proximity Read ↗

Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemiaSemantic proximity Read ↗

Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997.Semantic proximity Read ↗

Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations.Semantic proximity Read ↗

The multiple mechanisms of MCL1 in the regulation of cell fateSemantic proximity Read ↗

Bodyguards and assassins: Bcl‐2 family proteins and apoptosis control in chronic lymphocytic leukaemiaSemantic proximity Read ↗

BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemiaSemantic proximity Read ↗

Mcl-1 as a therapeutic target in acute myelogenous leukemia (AML)Semantic proximity Read ↗

MCL-1 is a prognostic indicator and drug target in breast cancerSemantic proximity Read ↗

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy BiomarkerSemantic proximity Read ↗

Targeting anti‐apoptotic BCL 2 family proteins in haematological malignancies – from pathogenesis to treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.