Distinct hypomyelinated phenotypes in MBP-SV40 large T transgenic mice.

doi:10.1002/jnr.490340302

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Article

Distinct hypomyelinated phenotypes in MBP-SV40 large T transgenic mice.

Journal of neuroscience research - 15 Feb 1993

Jensen N A, Smith G M, Shine H D, Garvey J S, Hood L

Abstract excerpt

To study the effect of SV40 large T-antigen expression in myelin-forming cells of both the central and peripheral nervous system, a series of transgenic mice were generated expressing the SV40 large T-antigen under control of the myelin basic protein (MBP) promoter. Two neurologic phenotypes, designated A and B, appeared among individual transgenic founders and their progeny. The A mice developed a severe action...

Topics

Animals
Antigens, Polyomavirus Transforming
Ataxia
Central Nervous System
Cloning, Molecular
DNA
Demyelinating Diseases
Female
Immunohistochemistry
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Mice, Transgenic

Microscopy, Electron

Myelin Basic Protein

Myelin Sheath

Oligodendroglia

Source

Open in PubMed

Identifiers

PMID: 7681114
DOI: 10.1002/jnr.490340302

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7681114-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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