Article
Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy.
Cell - 26 Aug 1994
Matsushima G K, Taniike M, Glimcher L H, Grusby M J, Frelinger J A, Suzuki K, Ting J P
Abstract excerpt
Globoid cell leukodystrophy (GLD) is a severe genetic demyelinating disorder with an increased number of Ia (immune response antigen) positive brain microglia/macrophages. To assess the role of aberrant Ia expression in the central nervous system (CNS), twitcher mice, which represent the murine m...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Bone Marrow Cells
- Central Nervous System
- Crosses, Genetic
- Disease Models, Animal
- Female
- Galactosylceramidase
- Genes, MHC Class II
- Histocompatibility Antigens Class II
- Leukodystrophy, Globoid Cell