Article
Fusion of human B cell lines with HIV-1 envelope-expressing T cells is enhanced by antigen-specific Ig receptors. Possible mechanism for elimination of gp120-specific B cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1993
Golding H, Dimitrov D S, Blackburn R, Manischewitz J, Blumenthal R, Golding B
Abstract excerpt
The possible contribution of Ag-specific Ig receptors on B cells to syncytium formation with HIV-1 envelope (env)-expressing cells was examined. A unique model system was designed that used anti-TNP/TNP interactions between a panel of TNP-specific human B cell lines and TNP-haptenated HIV-1 env-expressing T cells. The prototype B cell line 1:13 (CD4dull) produced few syncytia with vaccinia gp120/41-infected CD4-...
Topics
- B-Lymphocytes
- CD4 Antigens
- Cell Fusion
- Cell Line
- Cell Line, Transformed
- Epitopes
- HIV Envelope Protein gp120
- HIV Seropositivity
- Herpesvirus 4, Human
- Humans