Article
Incorporation of chimeric HIV-SIV-Env and modified HIV-Env proteins into HIV pseudovirions.
Virology - 10 May 2007
Devitt Gerard, Emerson Vanessa, Holtkotte Denise, Pfeiffer Tanya, Pisch Thorsten, Bosch Valerie
Abstract excerpt
Low level incorporation of the viral glycoprotein (Env) into human immunodeficiency virus (HIV) particles is a major drawback for vaccine strategies against HIV/AIDS in which HIV particles are used as immunogen. Within this study, we have examined two strategies aimed at achieving higher levels of Env incorporation into non-infectious pseudovirions (PVs). First, we have generated chimeric HIV/SIV Env proteins...
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