Article
HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1993
Chirmule N, Kalyanaraman V S, Lederman S, Oyaizu N, Yagura H, Yellin M J, Chess L, Pahwa S
Abstract excerpt
The HIV envelope glycoprotein gp160 has been previously demonstrated to induce differentiation of normal B lymphocytes into Ig-secreting cells; the response is T cell-dependent, and T cells pretreated with gp160 can support B cell differentiation. This study investigates the cell surface molecule...
Topics
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- Cell Communication
- Cell Differentiation
- Clone Cells
- Fixatives
- Formaldehyde
- Gene Products, env
- HIV Envelope Protein gp160
- HIV-1
- Humans
- Interleukin-6
- Lymphocyte Activation
- Lymphocyte Cooperation
- Major Histocompatibility Complex
- Phenotype
- Polymers