Article
HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1993
Chirmule N, Kalyanaraman V S, Lederman S, Oyaizu N, Yagura H, Yellin M J, Chess L, Pahwa S
Abstract excerpt
The HIV envelope glycoprotein gp160 has been previously demonstrated to induce differentiation of normal B lymphocytes into Ig-secreting cells; the response is T cell-dependent, and T cells pretreated with gp160 can support B cell differentiation. This study investigates the cell surface molecules and cytokines that play a role in the gp160-induced T-B cell interaction. Utilizing CD4+CD45RO+ cloned T cells as the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.