Variable region gene utilization and mutation in a group of neutralizing murine anti-human immunodeficiency virus type 1 principal neutralizing determinant antibodies.

doi:10.1089/aid.1993.9.41

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Article

Variable region gene utilization and mutation in a group of neutralizing murine anti-human immunodeficiency virus type 1 principal neutralizing determinant antibodies.

AIDS research and human retroviruses - 1 Jan 1993

Pirofski L A, Thomas E K, Scharff M D

Abstract excerpt

The heavy (VH) and light (VL) chain variable region nucleotide sequences of four neutralizing anti-human immunodeficiency virus type 1 (HIV-1) murine monoclonal antibodies (mAbs) were determined. These mAbs bind to native gp120, recombinant gp120, and a linear HIV-1 principal neutralizing determinant (PND) peptide that spans amino acid 308-328. Three mAbs that bind to the same linear determinant, 110.3, 110.4,...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Base Sequence
Epitopes
Gene Rearrangement
Genes, Immunoglobulin
HIV Antibodies
HIV Antigens
HIV-1
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulin Variable Region

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Neutralization Tests

Source

Open in PubMed

Identifiers

PMID: 7678971
DOI: 10.1089/aid.1993.9.41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7678971-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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