Article
Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120.
Molecular immunology - 1 Oct 1994
Bagley J, Dillon P J, Rosen C, Robinson J, Sodroski J, Marasco W A
Abstract excerpt
The human monoclonal antibodies (mAbs) 15e and 21h are derived from HIV-1-infected individuals. They block CD4 binding, recognize conformation-dependent discontinuous epitopes on gp120 and neutralize a broad range of laboratory strains and primary isolates of HIV-1. To determine if a structural b...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Binding Sites, Antibody
- CD4 Antigens
- Gene Expression
- Genes, Immunoglobulin
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Neutralization Tests