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Article

Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.

Immunology - 1 Apr 2015

Ellis Jason S, Braley-Mullen Helen

Abstract excerpt

NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) with chronic inflammation of thyroids by T and B cells. B-cell deficient (B(-/-) ) mice are resistant to SAT but develop SAT if regulatory T (Treg) cells are transiently depleted. We established a transfer model using splenocytes from CD28(-/-) B(-/-) mice (effector cells and antigen-presenting cells) cultured with or without sorted Treg cells from...

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Source

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Identifiers

PMID: 25318356
DOI: 10.1111/imm.12410
PMCID: PMC4368166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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