Article
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. II. Immunohistochemical studies on the thyroiditis lesion.
Regional immunology - 1 Jan 2000
Sugihara S, Maruo S, Tada T, Tsujimura T, Kohno Y, Hamaoka T, Fujiwara H
Abstract excerpt
The intravenous (i.v.) administration of Lyt-1dull T cells into syngeneic (C57BL/6 x C3H/He)F1 T cell-depleted B cell mice resulted in the induction of typical thyroiditis exhibiting massive cellular infiltration. The present study investigated which types of lymphoid cells infiltrate in the thyroiditis lesion and whether immunohistologic change takes place on epithelial cells of thyroid follicles. Both L3T4+ and...
Topics
- Animals
- B-Lymphocytes
- Epithelium
- Female
- Gene Expression
- Histocompatibility Antigens Class II
- Immunohistochemistry
- Inflammation
- Lymphocytes
- Macrophages
- Mice