Altered glycosylation of beta 1 integrins associated with reduced adhesiveness to fibronectin and laminin.

doi:10.1002/ijc.2910530118

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Article

Altered glycosylation of beta 1 integrins associated with reduced adhesiveness to fibronectin and laminin.

International journal of cancer - 2 Jan 1993

Kawano T, Takasaki S, Tao T W, Kobata A

Abstract excerpt

The carbohydrate structures of the beta 1 integrins obtained from a mouse metastatic melanoma B16 F1 and its weakly metastatic wheat-germ agglutinin-resistant mutant Wa4-b1 were studied comparatively. The results indicated that the integrins from both cells contain high mannose-type and bi-, tri-...

Topics

Animals
Carbohydrate Sequence
Cell Adhesion
Chromatography, Ion Exchange
Fibronectins
Glycosylation
Integrin beta1
Integrins
Laminin
Melanoma, Experimental
Mice
Molecular Sequence Data
Mutation
Oligosaccharides

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