Article
Altered glycosylation of beta 1 integrins associated with reduced adhesiveness to fibronectin and laminin.
International journal of cancer - 2 Jan 1993
Kawano T, Takasaki S, Tao T W, Kobata A
Abstract excerpt
The carbohydrate structures of the beta 1 integrins obtained from a mouse metastatic melanoma B16 F1 and its weakly metastatic wheat-germ agglutinin-resistant mutant Wa4-b1 were studied comparatively. The results indicated that the integrins from both cells contain high mannose-type and bi-, tri- and tetra-antennary complex-type sugar chains. No significant difference was found in the outer chain branching...
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