Article
An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III.
The Journal of biological chemistry - 1 May 2009
Sato Yuya, Isaji Tomoya, Tajiri Michiko, Yoshida-Yamamoto Shumi, Yoshinaka Tsuyoshi, Somehara Toshiaki, Fukuda Tomohiko, Wada Yoshinao, Gu Jianguo
Abstract excerpt
Recently we reported that N-glycans on the beta-propeller domain of the integrin alpha5 subunit (S-3,4,5) are essential for alpha5beta1 heterodimerization, expression, and cell adhesion. Herein to further investigate which N-glycosylation site is the most important for the biological function and regulation, we characterized the S-3,4,5 mutants in detail. We found that site-4 is a key site that can be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.